And lastly, clonidine boosts neuraxial opioids and, together with fentanyl, interacts in an additive method, that may decrease the dose of every part by 60% for postoperative analgesia.Jun ten, 2024 · If clonidine therapy will be to be replaced by a ?-blocker, delay administration of your ?-blocker for a number of days after clonidine therapy has